Member of an artist family, Stern is the daughter of actor/producer Tom Stern and Academy award-nominated and Golden Globe-winning actress Samantha Eggar. Her brother, Nicolas Stern, is a producer for film and television. She married actor Brennan Brown in 1998, and they live in Brooklyn, New York.
Stern graduated from the U.C. Berkeley with a B.A. and received her M.F.A. from NYU Graduate School.